H2N2V1, France, Analysis, bibRecord, 000244

Induction of neutralising antibodies by virus-like particles harbouring surface proteins from highly pathogenic H5N1 and H7N1 influenza viruses.

Identifieur interne : 000244 ( France/Analysis ); précédent : 000243; suivant : 000245

Induction of neutralising antibodies by virus-like particles harbouring surface proteins from highly pathogenic H5N1 and H7N1 influenza viruses.

Auteurs : Judit Szécsi [France] ; Bertrand Boson [France] ; Per Johnsson [France] ; Pia Dupeyrot-Lacas [France] ; Mikhail Matrosovich [Allemagne] ; Hans-Dieter Klenk [Allemagne] ; David Klatzmann [France] ; Viktor Volchkov [France] ; François-Loïc Cosset [France]

Source :

RBID : Hal:inserm-00097847

Abstract

SUMMARY: There is an urgent need to develop novel approaches to vaccination against the emerging, highly pathogenic avian influenza viruses. Here, we engineered influenza viral-like particles (Flu-VLPs) derived from retroviral core particles that mimic the properties of the viral surface of two highly pathogenic influenza viruses of either H7N1 or H5N1 antigenic subtype. We demonstrate that, upon recovery of viral RNAs from a field strain, one can easily generate expression vectors that encode the HA, NA and M2 surface proteins of either virus and prepare high-titre Flu-VLPs. We characterise these Flu-VLPs incorporating the HA, NA and M2 proteins and we show that they induce high-titre neutralising antibodies in mice.

Url:

https://www.hal.inserm.fr/inserm-00097847

DOI: 10.1186/1743-422X-3-70

Affiliations:

Allemagne, France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000154
to stream Hal, to step Curation: 000154
to stream Hal, to step Checkpoint: 000325
to stream Main, to step Merge: 001478
to stream Main, to step Curation: 001459
to stream Main, to step Exploration: 001459
to stream France, to step Extraction: 000244

Links to Exploration step

Hal:inserm-00097847

Le document en format XML

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</hal:affiliation>
<country>France</country>
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<author><name sortKey="Johnsson, Per" sort="Johnsson, Per" uniqKey="Johnsson P" first="Per" last="Johnsson">Per Johnsson</name>
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          <orgName>École normale supérieure - Lyon</orgName>
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<tutelle name="U758" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Dupeyrot Lacas, Pia" sort="Dupeyrot Lacas, Pia" uniqKey="Dupeyrot Lacas P" first="Pia" last="Dupeyrot-Lacas">Pia Dupeyrot-Lacas</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2832" status="OLD">          <orgName>Virologie humaine</orgName>
          <desc>            <address>              <addrLine>46, Allee D'Italie 69364 LYON CEDEX 07</addrLine>
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          <orgName>École normale supérieure - Lyon</orgName>
          <orgName type="acronym">ENS Lyon</orgName>
          <desc>            <address>              <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
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<tutelle name="U758" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-20544" status="INCOMING">          <orgName>Institut fur Virologie</orgName>
          <desc>            <address>              <addrLine>D-35033 Marburg</addrLine>
              <country key="DE"></country>
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</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-20544" status="INCOMING">          <orgName>Institut fur Virologie</orgName>
          <desc>            <address>              <addrLine>D-35033 Marburg</addrLine>
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</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Klatzmann, David" sort="Klatzmann, David" uniqKey="Klatzmann D" first="David" last="Klatzmann">David Klatzmann</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1031" status="OLD">          <orgName>Biologie et thérapeutique des pathologies immunitaires</orgName>
          <orgName type="acronym">BTPI</orgName>
          <desc>            <address>              <addrLine>bat. CERVI 83 Bvd de l'hôpital 75651 PARIS CEDEX 13</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://web.ccr.jussieu.fr/lab/p6/ufr965/lab23/d.html</ref>
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          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
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<country>France</country>
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</author>
<author><name sortKey="Volchkov, Viktor" sort="Volchkov, Viktor" uniqKey="Volchkov V" first="Viktor" last="Volchkov">Viktor Volchkov</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2832" status="OLD">          <orgName>Virologie humaine</orgName>
          <desc>            <address>              <addrLine>46, Allee D'Italie 69364 LYON CEDEX 07</addrLine>
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          <orgName>École normale supérieure - Lyon</orgName>
          <orgName type="acronym">ENS Lyon</orgName>
          <desc>            <address>              <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
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<tutelle name="U758" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Cosset, Francois Loic" sort="Cosset, Francois Loic" uniqKey="Cosset F" first="François-Loïc" last="Cosset">François-Loïc Cosset</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2832" status="OLD">          <orgName>Virologie humaine</orgName>
          <desc>            <address>              <addrLine>46, Allee D'Italie 69364 LYON CEDEX 07</addrLine>
              <country key="FR"></country>
            </address>
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          <orgName>École normale supérieure - Lyon</orgName>
          <orgName type="acronym">ENS Lyon</orgName>
          <desc>            <address>              <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ens-lyon.eu/</ref>
          </desc>
        </org>
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<tutelle active="#struct-300626" type="direct"><org type="institution" xml:id="struct-300626" status="VALID">          <orgName>IFR128</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="U758" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1186/1743-422X-3-70</idno>
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</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>SUMMARY: There is an urgent need to develop novel approaches to vaccination against the emerging, highly pathogenic avian influenza viruses. Here, we engineered influenza viral-like particles (Flu-VLPs) derived from retroviral core particles that mimic the properties of the viral surface of two highly pathogenic influenza viruses of either H7N1 or H5N1 antigenic subtype. We demonstrate that, upon recovery of viral RNAs from a field strain, one can easily generate expression vectors that encode the HA, NA and M2 surface proteins of either virus and prepare high-titre Flu-VLPs. We characterise these Flu-VLPs incorporating the HA, NA and M2 proteins and we show that they induce high-titre neutralising antibodies in mice.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Szecsi, Judit" sort="Szecsi, Judit" uniqKey="Szecsi J" first="Judit" last="Szécsi">Judit Szécsi</name>
</noRegion>
<name sortKey="Boson, Bertrand" sort="Boson, Bertrand" uniqKey="Boson B" first="Bertrand" last="Boson">Bertrand Boson</name>
<name sortKey="Cosset, Francois Loic" sort="Cosset, Francois Loic" uniqKey="Cosset F" first="François-Loïc" last="Cosset">François-Loïc Cosset</name>
<name sortKey="Dupeyrot Lacas, Pia" sort="Dupeyrot Lacas, Pia" uniqKey="Dupeyrot Lacas P" first="Pia" last="Dupeyrot-Lacas">Pia Dupeyrot-Lacas</name>
<name sortKey="Johnsson, Per" sort="Johnsson, Per" uniqKey="Johnsson P" first="Per" last="Johnsson">Per Johnsson</name>
<name sortKey="Klatzmann, David" sort="Klatzmann, David" uniqKey="Klatzmann D" first="David" last="Klatzmann">David Klatzmann</name>
<name sortKey="Volchkov, Viktor" sort="Volchkov, Viktor" uniqKey="Volchkov V" first="Viktor" last="Volchkov">Viktor Volchkov</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name>
</noRegion>
<name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Induction of neutralising antibodies by virus-like particles harbouring surface proteins from highly pathogenic H5N1 and H7N1 influenza viruses.
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Induction of neutralising antibodies by virus-like particles harbouring surface proteins from highly pathogenic H5N1 and H7N1 influenza viruses.

Induction of neutralising antibodies by virus-like particles harbouring surface proteins from highly pathogenic H5N1 and H7N1 influenza viruses.

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